1) Aged 18-90 years2) PaO2/FiO2 (PFI) below 200 mmHg (26.7 kPa)3) Suspected or verified SARS-CoV-2 infection4) At least two risk factors for increased morbidity/mortality• Age above 50 years• Hypertension• Cardiovascular disease• Diabetes or pre-diabetes• Active or cured cancer• Asthma/COPD• Smoking• D-Dimer > 1.0• Auto-immune disease5) Documented informed consent according to ICH-GCP and national regulations

1) Aged 18-90 years2) PaO2/FiO2 (PFI) below 200 mmHg (26.7 kPa)3) Suspected or verified SARS-CoV-2 infection4) At least two risk factors for increased morbidity/mortality• Age above 50 years• Hypertension• Cardiovascular disease• Diabetes or pre-diabetes• Active or cured cancer• Asthma/COPD• Smoking• D-Dimer > 1.0• Auto-immune disease5) Documented informed consent according to ICH-GCP and national regulations