inclusion criteria: - sars-cov-2 pcr-confirmed covid-19 infection - presence of acute hypoxic respiratory failure defined as (either or both) - saturation < 94% on room air or requiring supplemental oxygen - pao2/fio2 below 350 - age 21-80 - able and willing to provide informed consent

inclusion criteria: - sars-cov-2 pcr-confirmed covid-19 infection - presence of acute hypoxic respiratory failure defined as (either or both) - saturation < 94% on room air or requiring supplemental oxygen - pao2/fio2 below 350 - age 21-80 - able and willing to provide informed consent