- patients who are treated with or require high flow nasal cannula, cpap, intubation, mechanical ventilation, or tracheostomy - diagnosis of acute respiratory distress syndrome - subjects diagnosed with immunodeficiency, with history of congestive or unstable heart disease, left ventricular dysfunction or myocardial damage, severe pulmonary hypertension and/or unstable hypertension - patients receiving drugs that have contraindications with no. - breastfeeding or pregnancy as evidenced by a positive pregnancy test. - patients with active pulmonary malignancy or lung transplant - patients with a history of frequent epistaxis or significant hemoptysis

- patients who are treated with or require high flow nasal cannula, cpap, intubation, mechanical ventilation, or tracheostomy - diagnosis of acute respiratory distress syndrome - subjects diagnosed with immunodeficiency, with history of congestive or unstable heart disease, left ventricular dysfunction or myocardial damage, severe pulmonary hypertension and/or unstable hypertension - patients receiving drugs that have contraindications with no. - breastfeeding or pregnancy as evidenced by a positive pregnancy test. - patients with active pulmonary malignancy or lung transplant - patients with a history of frequent epistaxis or significant hemoptysis