- heparin allergy - active bleeding - death or withdraw of care anticipated by intensivist within 24 hours - platelets< 50,000 cells/µl - clinically significant coagulopathy, as decided by the intensivist - o2 dependent at baseline

- heparin allergy - active bleeding - death or withdraw of care anticipated by intensivist within 24 hours - platelets< 50,000 cells/µl - clinically significant coagulopathy, as decided by the intensivist - o2 dependent at baseline