- family history of seizure, epilepsy, brain or mental disease - subject allergic to any component of the investigational vaccine, or a more severe allergic reaction and history of allergies in the past. - woman who is pregnant, breast-feeding or positive in β-hcg (human chorionic gonadotropin) pregnancy test (urine) on day of enrollment, or become pregnant during the next 6 months - any acute fever disease or infections. - history of sars - major congenital defects or not well-controlled chronic illness, such as asthma, diabetes, or thyroid disease. - serious cardiovascular diseases, such as arrhythmia, conduction block, myocardial infarction, severe hypertension without controllable drugs, etc. - hereditary angioneurotic edema or acquired angioneurotic edema - urticaria in last one year - no spleen or functional spleen. - platelet disorder or other bleeding disorder may cause injection contraindication - faint at the sight of needles. - prior administration of immunodepressant or corticosteroids, antianaphylaxis treatment, cytotoxic treatment in last 6 months. - prior administration of blood products in last 4 months - prior administration of other research medicines in last 1 month - prior administration of attenuated vaccine in last 1 month - prior administration of inactivated vaccine in last 14 days - current anti-tuberculosis prophylaxis or therapy - according to the judgement of investigator,various medical, psychological, social or other conditions, those could affect the subjects to sign informed consent.

- family history of seizure, epilepsy, brain or mental disease - subject allergic to any component of the investigational vaccine, or a more severe allergic reaction and history of allergies in the past. - woman who is pregnant, breast-feeding or positive in β-hcg (human chorionic gonadotropin) pregnancy test (urine) on day of enrollment, or become pregnant during the next 6 months - any acute fever disease or infections. - history of sars - major congenital defects or not well-controlled chronic illness, such as asthma, diabetes, or thyroid disease. - serious cardiovascular diseases, such as arrhythmia, conduction block, myocardial infarction, severe hypertension without controllable drugs, etc. - hereditary angioneurotic edema or acquired angioneurotic edema - urticaria in last one year - no spleen or functional spleen. - platelet disorder or other bleeding disorder may cause injection contraindication - faint at the sight of needles. - prior administration of immunodepressant or corticosteroids, antianaphylaxis treatment, cytotoxic treatment in last 6 months. - prior administration of blood products in last 4 months - prior administration of other research medicines in last 1 month - prior administration of attenuated vaccine in last 1 month - prior administration of inactivated vaccine in last 14 days - current anti-tuberculosis prophylaxis or therapy - according to the judgement of investigator,various medical, psychological, social or other conditions, those could affect the subjects to sign informed consent.