- simultaneous participation in any other clinical study incompatible with this one - treatment with an antibody immunotherapy within 4 weeks of screening - requirement for mechanical ventilation or ecmo at screening - hypotension at screening - severe liver injury defined as ast or alt ≥5x the upper limit of normal - severe kidney failure defined as an estimated glomerular filtration rate (egfr) <30 ml/min - pregnancy or breastfeeding - > 120 hours between admission and signing consent

- simultaneous participation in any other clinical study incompatible with this one - treatment with an antibody immunotherapy within 4 weeks of screening - requirement for mechanical ventilation or ecmo at screening - hypotension at screening - severe liver injury defined as ast or alt ≥5x the upper limit of normal - severe kidney failure defined as an estimated glomerular filtration rate (egfr) <30 ml/min - pregnancy or breastfeeding - > 120 hours between admission and signing consent