inclusion criteria: for plasma donors: - over 18 years of age - men or nulliparous women with no history of recent abortions or transfusions sars-cov-2 infection by pcr in any sample or serological test with a maximum of 60 days from resolution of symptoms. - if donation is done within 14 to 28 days after resolution of symptoms, the patient must have a negative pcr test for sars-cov-2. if donation is done after 28 days of resolving symptoms, no negative control test will be required. for plasma recipients: - over 18 years of age - sars-cov-2 infection confirmed by pcr in any sample - hospitalized in the icu due to shock or respiratory failure, with less than 24 hours after entering the icu.

inclusion criteria: for plasma donors: - over 18 years of age - men or nulliparous women with no history of recent abortions or transfusions sars-cov-2 infection by pcr in any sample or serological test with a maximum of 60 days from resolution of symptoms. - if donation is done within 14 to 28 days after resolution of symptoms, the patient must have a negative pcr test for sars-cov-2. if donation is done after 28 days of resolving symptoms, no negative control test will be required. for plasma recipients: - over 18 years of age - sars-cov-2 infection confirmed by pcr in any sample - hospitalized in the icu due to shock or respiratory failure, with less than 24 hours after entering the icu.