- current pregnancy. - cardiac rhythm abnormalities with instability. - acute congestive heart failure/cardiogenic shock. - severe comorbidities affecting mortality as defined by research group. - cancer history in the past 5 years. - hiv, syphilis, hepatitis b or c. - concomitant use of immunosuppressive therapy with contraindication to msc. - fivefold elevation of liver enzymes (alt, ast). - chronic kidney disease with glomerular filtration rate below 30ml/min or dialytic needs.

- current pregnancy. - cardiac rhythm abnormalities with instability. - acute congestive heart failure/cardiogenic shock. - severe comorbidities affecting mortality as defined by research group. - cancer history in the past 5 years. - hiv, syphilis, hepatitis b or c. - concomitant use of immunosuppressive therapy with contraindication to msc. - fivefold elevation of liver enzymes (alt, ast). - chronic kidney disease with glomerular filtration rate below 30ml/min or dialytic needs.