- age <18 ys or >65 - patients in mechanical ventilation at time of admission - severe hearth failure (nyha 3 or 4) - qtc > 470 ms or >500 ms in wide qrs patients - severe history of chronic ischemic heart disease, defined as history of major adverse cardiovascular event and/or recent (one year) revascularization. - history of recurrent deep venous thrombosis and pulmonary embolism or established thrombophilic conditions (e.g. history of anti-phospholipid antibodies, …) - active bacterial or fungal infection - hematological cancer - metastatic or intractable cancer - pre-existent neurodegenerative disease - severe hepatic impairment, - history of acute diverticular disease or intestinal perforation - hbsag positive and/or hbv-dna positive patients - severe renal failure (creatinine clearance <30ml/h) - active herpes zoster infection - patients with active or latent tb - severe anemia (hb<9g/dl) - lymphocyte count below 750/mcl - neutrophil count below 1000/mcl - platelet count below 50000/mcl - pregnancy or lactation - history of intolerance to the experimental drugs or excipients - degenerative maculopathy or other relevant retinal disease - inability to give informed consent (severe transitory or permanent mental impairment, incapacitation)

- age <18 ys or >65 - patients in mechanical ventilation at time of admission - severe hearth failure (nyha 3 or 4) - qtc > 470 ms or >500 ms in wide qrs patients - severe history of chronic ischemic heart disease, defined as history of major adverse cardiovascular event and/or recent (one year) revascularization. - history of recurrent deep venous thrombosis and pulmonary embolism or established thrombophilic conditions (e.g. history of anti-phospholipid antibodies, …) - active bacterial or fungal infection - hematological cancer - metastatic or intractable cancer - pre-existent neurodegenerative disease - severe hepatic impairment, - history of acute diverticular disease or intestinal perforation - hbsag positive and/or hbv-dna positive patients - severe renal failure (creatinine clearance <30ml/h) - active herpes zoster infection - patients with active or latent tb - severe anemia (hb<9g/dl) - lymphocyte count below 750/mcl - neutrophil count below 1000/mcl - platelet count below 50000/mcl - pregnancy or lactation - history of intolerance to the experimental drugs or excipients - degenerative maculopathy or other relevant retinal disease - inability to give informed consent (severe transitory or permanent mental impairment, incapacitation)