a potential participant who met any of the following criteria was not eligible to participate in the study: was currently receiving invasive mechanical ventilation (e.g., via an endotracheal tube) (score of 2 on niaid ordinal scale). had severe chronic respiratory disease, defined by any oxygen requirement prior to incident covid-19. had active or uncontrolled bleeding at the time of randomization; a bleeding disorder, either inherited or caused by disease; history of known arterial-venous malformation, intracranial hemorrhage, or suspected or known cerebral aneurysm; or clinically significant (in the judgment of the investigator) gastrointestinal bleeding within the 3 weeks prior to randomization. was receiving any other investigational (non-approved) therapy for the treatment of covid-19 or participating in the treatment period of any other therapeutic intervention clinical study. participating in the follow-up period of an interventional study may be permitted with prior medical monitor approval; participation in an observational study is permitted. was receiving systemic corticosteroids for a chronic condition. was receiving chronic anticoagulation with warfarin or direct oral anticoagulants (e.g., rivaroxaban, dabigatran, apixaban, edoxaban). was receiving or anticipated to require other systemic anticoagulation dosing at a therapeutic intensity. prophylaxis of venous thromboembolism (vte) using subcutaneous (sc) unfractionated heparin or enoxaparin was permitted with appropriate monitoring of coagulation status and within the guidelines described in the protocol. was receiving antiplatelet therapy, alone or in combination, including aspirin and other antiplatelet agents (e.g., clopidogrel, ticagrelor, and prasugrel), unless able to discontinue these agents at the time of randomization and was able to remain off these agents throughout the duration of the study intervention infusion period. had treatment with systemic (non-steroid) immunomodulators or immunosuppressant medications, including but not limited to tumor necrosis factor (tnf) inhibitors, anti-interleukin-1 agents and janus kinase (jak) inhibitors within 5 half-lives or 30 days (whichever was longer) prior to randomization. had a history of congestive heart failure requiring hospitalization. had active pericarditis (based on clinical assessment). had malignancy or other irreversible disease or condition for which 6-month mortality was estimated ≥50%. had a corrected qt interval (qtc) >500 msec (or >530-550 msec in participants with qrs greater than >120 msec). had a tisdale risk score ≥11 without the ability to monitor with serial electrocardiograms (ecgs) or telemetry. had severe renal impairment, as determined by calculated creatinine clearance <30 ml/min or estimated glomerular filtration rate (egfr) <30 ml/min/1.73 m2. had alanine aminotransferase (alt) or aspartate aminotransferase (ast) values >5x upper limit of normal (uln). had activated partial thromboplastin time (aptt) >42 seconds. had thrombocytopenia with a platelet count <80,000/mm3. had severe chronic liver disease (child-pugh score of 10 to 15). had received dociparstat in a different clinical study. woman of childbearing potential who was pregnant, breastfeeding, and/or not using a highly-effective method of contraception (consistent with local regulations regarding the methods of contraception for those participating in clinical studies). had evidence of clinical improvement in covid-19 status including, but not limited to, a sustained reduction in oxygen requirements over the previous 48 hours, or extubated and/or no longer requiring mechanical ventilation following intubation for covid-19. had any other condition, including abnormal laboratory values, that, in the judgment of the investigator, could have put the participant at increased risk, or would have interfered with the conduct or planned analysis of the study.

a potential participant who met any of the following criteria was not eligible to participate in the study: was currently receiving invasive mechanical ventilation (e.g., via an endotracheal tube) (score of 2 on niaid ordinal scale). had severe chronic respiratory disease, defined by any oxygen requirement prior to incident covid-19. had active or uncontrolled bleeding at the time of randomization; a bleeding disorder, either inherited or caused by disease; history of known arterial-venous malformation, intracranial hemorrhage, or suspected or known cerebral aneurysm; or clinically significant (in the judgment of the investigator) gastrointestinal bleeding within the 3 weeks prior to randomization. was receiving any other investigational (non-approved) therapy for the treatment of covid-19 or participating in the treatment period of any other therapeutic intervention clinical study. participating in the follow-up period of an interventional study may be permitted with prior medical monitor approval; participation in an observational study is permitted. was receiving systemic corticosteroids for a chronic condition. was receiving chronic anticoagulation with warfarin or direct oral anticoagulants (e.g., rivaroxaban, dabigatran, apixaban, edoxaban). was receiving or anticipated to require other systemic anticoagulation dosing at a therapeutic intensity. prophylaxis of venous thromboembolism (vte) using subcutaneous (sc) unfractionated heparin or enoxaparin was permitted with appropriate monitoring of coagulation status and within the guidelines described in the protocol. was receiving antiplatelet therapy, alone or in combination, including aspirin and other antiplatelet agents (e.g., clopidogrel, ticagrelor, and prasugrel), unless able to discontinue these agents at the time of randomization and was able to remain off these agents throughout the duration of the study intervention infusion period. had treatment with systemic (non-steroid) immunomodulators or immunosuppressant medications, including but not limited to tumor necrosis factor (tnf) inhibitors, anti-interleukin-1 agents and janus kinase (jak) inhibitors within 5 half-lives or 30 days (whichever was longer) prior to randomization. had a history of congestive heart failure requiring hospitalization. had active pericarditis (based on clinical assessment). had malignancy or other irreversible disease or condition for which 6-month mortality was estimated ≥50%. had a corrected qt interval (qtc) >500 msec (or >530-550 msec in participants with qrs greater than >120 msec). had a tisdale risk score ≥11 without the ability to monitor with serial electrocardiograms (ecgs) or telemetry. had severe renal impairment, as determined by calculated creatinine clearance <30 ml/min or estimated glomerular filtration rate (egfr) <30 ml/min/1.73 m2. had alanine aminotransferase (alt) or aspartate aminotransferase (ast) values >5x upper limit of normal (uln). had activated partial thromboplastin time (aptt) >42 seconds. had thrombocytopenia with a platelet count <80,000/mm3. had severe chronic liver disease (child-pugh score of 10 to 15). had received dociparstat in a different clinical study. woman of childbearing potential who was pregnant, breastfeeding, and/or not using a highly-effective method of contraception (consistent with local regulations regarding the methods of contraception for those participating in clinical studies). had evidence of clinical improvement in covid-19 status including, but not limited to, a sustained reduction in oxygen requirements over the previous 48 hours, or extubated and/or no longer requiring mechanical ventilation following intubation for covid-19. had any other condition, including abnormal laboratory values, that, in the judgment of the investigator, could have put the participant at increased risk, or would have interfered with the conduct or planned analysis of the study.

currently receiving invasive mechanical ventilation (e.g., via an endotracheal tube) (score of 2 on niaid ordinal scale). active or uncontrolled bleeding at the time of randomization; a bleeding disorder, either inherited or caused by disease; history of known arterial-venous malformation, intracranial hemorrhage, or suspected or known cerebral aneurysm; or clinically significant (in the judgment of the investigator) gastrointestinal bleeding within the 3 weeks prior to randomization. receiving any other investigational (non-approved) therapy for the treatment of covid-19 or participating in the treatment period of any other therapeutic invention clinical study. receiving systemic corticosteroids for a chronic condition. receiving chronic anticoagulation with warfarin or direct oral anticoagulants (e.g., rivaroxaban, dabigatran, apixaban, edoxaban). receiving or anticipated to require other systemic anticoagulation dosing at a therapeutic intensity. prophylaxis of vte using sc unfractionated heparin or enoxaparin is permitted with appropriate monitoring of coagulation status and within guidelines provided in the protocol. receiving antiplatelet therapy, alone or in combination, including aspirin and other antiplatelet agents (e.g., clopidogrel, ticagrelor, and prasugrel), unless able to discontinue these agents at the time of randomization and to remain off these agents throughout the duration of the study intervention infusion period. treatment with systemic (nonsteroid) immunomodulators or immunosuppressant medications, including but not limited to tnf inhibitors, anti-interleukin-1 agents, and janus kinase (jak) inhibitors within 5 half-lives or 30 days (whichever is longer) prior to randomization. severe chronic liver disease. severe renal impairment. qtc >500 msec (or >530-550 msec in patients with qrs greater than >120 msec). alanine aminotransferase (alt) or aspartate aminotransferase (ast) >5x upper limit of normal (uln). activated partial thromboplastin time (aptt) >42 seconds. thrombocytopenia with a platelet count <80,000/mm3. evidence of clinical improvement in covid-19 status including, but not limited to, a sustained reduction in oxygen requirements over the previous 48 hours, or extubated and/or no longer requiring mechanical ventilation following intubation for covid-19. any other condition, including abnormal laboratory values, that, in the judgment of the investigator, could put the participant at increased risk, or would interfere with the conduct or planned analysis of the study.

currently receiving invasive mechanical ventilation (e.g., via an endotracheal tube) (score of 2 on niaid ordinal scale). active or uncontrolled bleeding at the time of randomization; a bleeding disorder, either inherited or caused by disease; history of known arterial-venous malformation, intracranial hemorrhage, or suspected or known cerebral aneurysm; or clinically significant (in the judgment of the investigator) gastrointestinal bleeding within the 3 weeks prior to randomization. receiving any other investigational (non-approved) therapy for the treatment of covid-19 or participating in the treatment period of any other therapeutic invention clinical study. receiving systemic corticosteroids for a chronic condition. receiving chronic anticoagulation with warfarin or direct oral anticoagulants (e.g., rivaroxaban, dabigatran, apixaban, edoxaban). receiving or anticipated to require other systemic anticoagulation dosing at a therapeutic intensity. prophylaxis of vte using sc unfractionated heparin or enoxaparin is permitted with appropriate monitoring of coagulation status and within guidelines provided in the protocol. receiving antiplatelet therapy, alone or in combination, including aspirin and other antiplatelet agents (e.g., clopidogrel, ticagrelor, and prasugrel), unless able to discontinue these agents at the time of randomization and to remain off these agents throughout the duration of the study intervention infusion period. treatment with systemic (nonsteroid) immunomodulators or immunosuppressant medications, including but not limited to tnf inhibitors, anti-interleukin-1 agents, and janus kinase (jak) inhibitors within 5 half-lives or 30 days (whichever is longer) prior to randomization. severe chronic liver disease. severe renal impairment. qtc >500 msec (or >530-550 msec in patients with qrs greater than >120 msec). alanine aminotransferase (alt) or aspartate aminotransferase (ast) >5x upper limit of normal (uln). activated partial thromboplastin time (aptt) >42 seconds. thrombocytopenia with a platelet count <80,000/mm3. evidence of clinical improvement in covid-19 status including, but not limited to, a sustained reduction in oxygen requirements over the previous 48 hours, or extubated and/or no longer requiring mechanical ventilation following intubation for covid-19. any other condition, including abnormal laboratory values, that, in the judgment of the investigator, could put the participant at increased risk, or would interfere with the conduct or planned analysis of the study.

1. currently receiving invasive mechanical ventilation (e.g., via an endotracheal tube) (score of 2 on niaid ordinal scale). 2. active or uncontrolled bleeding at the time of randomization; a bleeding disorder, either inherited or caused by disease; history of known arterial-venous malformation, intracranial hemorrhage, or suspected or known cerebral aneurysm; or clinically significant (in the judgment of the investigator) gastrointestinal bleeding within the 3 weeks prior to randomization. 3. receiving any other investigational (non-approved) therapy for the treatment of covid-19 or participating in the treatment period of any other therapeutic invention clinical study. 4. receiving systemic corticosteroids for a chronic condition. 5. receiving chronic anticoagulation with warfarin or direct oral anticoagulants (e.g., rivaroxaban, dabigatran, apixaban, edoxaban). 6. receiving or anticipated to require other systemic anticoagulation dosing at a therapeutic intensity. prophylaxis of vte using sc unfractionated heparin or enoxaparin is permitted with appropriate monitoring of coagulation status and within guidelines provided in the protocol. 7. receiving antiplatelet therapy, alone or in combination, including aspirin and other antiplatelet agents (e.g., clopidogrel, ticagrelor, and prasugrel), unless able to discontinue these agents at the time of randomization and to remain off these agents throughout the duration of the study intervention infusion period. 8. treatment with systemic (nonsteroid) immunomodulators or immunosuppressant medications, including but not limited to tnf inhibitors, anti-interleukin-1 agents, and janus kinase (jak) inhibitors within 5 half-lives or 30 days (whichever is longer) prior to randomization. 9. severe chronic liver disease. 10. severe renal impairment. 11. qtc >500 msec (or >530-550 msec in patients with qrs greater than >120 msec). 12. alanine aminotransferase (alt) or aspartate aminotransferase (ast) >5x upper limit of normal (uln). 13. activated partial thromboplastin time (aptt) >42 seconds. 14. thrombocytopenia with a platelet count <80,000/mm3. 15. evidence of clinical improvement in covid-19 status including, but not limited to, a sustained reduction in oxygen requirements over the previous 48 hours, or extubated and/or no longer requiring mechanical ventilation following intubation for covid-19. 16. any other condition, including abnormal laboratory values, that, in the judgment of the investigator, could put the participant at increased risk, or would interfere with the conduct or planned analysis of the study.

1. currently receiving invasive mechanical ventilation (e.g., via an endotracheal tube) (score of 2 on niaid ordinal scale). 2. active or uncontrolled bleeding at the time of randomization; a bleeding disorder, either inherited or caused by disease; history of known arterial-venous malformation, intracranial hemorrhage, or suspected or known cerebral aneurysm; or clinically significant (in the judgment of the investigator) gastrointestinal bleeding within the 3 weeks prior to randomization. 3. receiving any other investigational (non-approved) therapy for the treatment of covid-19 or participating in the treatment period of any other therapeutic invention clinical study. 4. receiving systemic corticosteroids for a chronic condition. 5. receiving chronic anticoagulation with warfarin or direct oral anticoagulants (e.g., rivaroxaban, dabigatran, apixaban, edoxaban). 6. receiving or anticipated to require other systemic anticoagulation dosing at a therapeutic intensity. prophylaxis of vte using sc unfractionated heparin or enoxaparin is permitted with appropriate monitoring of coagulation status and within guidelines provided in the protocol. 7. receiving antiplatelet therapy, alone or in combination, including aspirin and other antiplatelet agents (e.g., clopidogrel, ticagrelor, and prasugrel), unless able to discontinue these agents at the time of randomization and to remain off these agents throughout the duration of the study intervention infusion period. 8. treatment with systemic (nonsteroid) immunomodulators or immunosuppressant medications, including but not limited to tnf inhibitors, anti-interleukin-1 agents, and janus kinase (jak) inhibitors within 5 half-lives or 30 days (whichever is longer) prior to randomization. 9. severe chronic liver disease. 10. severe renal impairment. 11. qtc >500 msec (or >530-550 msec in patients with qrs greater than >120 msec). 12. alanine aminotransferase (alt) or aspartate aminotransferase (ast) >5x upper limit of normal (uln). 13. activated partial thromboplastin time (aptt) >42 seconds. 14. thrombocytopenia with a platelet count <80,000/mm3. 15. evidence of clinical improvement in covid-19 status including, but not limited to, a sustained reduction in oxygen requirements over the previous 48 hours, or extubated and/or no longer requiring mechanical ventilation following intubation for covid-19. 16. any other condition, including abnormal laboratory values, that, in the judgment of the investigator, could put the participant at increased risk, or would interfere with the conduct or planned analysis of the study.