- mews score > 4 - severe multiple organ failure - recent cardiomyopathy, unstable angina, acute myocardial infarction - severe kidney failure with glomerular filtration rate less than 30 ml/min or renal replacement therapy or peritoneal dialysis - history of diabetes insipidus or severe hyponatremia (<128 meq/l) or hypernatremia (>155 meq/l) - qt interval which in the opinion of the patient's treating physician contraindicates therapy with ot - state of shock - women who are pregnant or nursing - known intolerance or hypersensitivity to the drug or its excipients - treatment with antirejection agents - individuals with severe liver failure - patients enrolled in other clinical trials

- mews score > 4 - severe multiple organ failure - recent cardiomyopathy, unstable angina, acute myocardial infarction - severe kidney failure with glomerular filtration rate less than 30 ml/min or renal replacement therapy or peritoneal dialysis - history of diabetes insipidus or severe hyponatremia (<128 meq/l) or hypernatremia (>155 meq/l) - qt interval which in the opinion of the patient's treating physician contraindicates therapy with ot - state of shock - women who are pregnant or nursing - known intolerance or hypersensitivity to the drug or its excipients - treatment with antirejection agents - individuals with severe liver failure - patients enrolled in other clinical trials