inclusion criteria: over 18 years old male or female documented pcr sars-cov-2 positive test covid-19 convalescence (define as at least 10 days after the onset of symptoms, no fever for at least 24 hours without the use of antipyretics and improvement of respiratory symptoms) informed consent signed clinical severity presentation of severe the disease is classified as severe if one of the following conditions is met: respiratory distress, respiratory rate ≥30/min oxygen saturation on room air at rest ≤93%. partial pressure of oxygen in arterial blood/fio2 ≤300 mm hg. or critical if one of the following conditions is met. respiratory failure and mechanical ventilation are required. shock occurs another organ dysfunction is present risk of health complication >50% according to the health risk calculator less than 14 days of hospital discharge.

inclusion criteria: over 18 years old male or female documented pcr sars-cov-2 positive test covid-19 convalescence (define as at least 10 days after the onset of symptoms, no fever for at least 24 hours without the use of antipyretics and improvement of respiratory symptoms) informed consent signed clinical severity presentation of severe the disease is classified as severe if one of the following conditions is met: respiratory distress, respiratory rate ≥30/min oxygen saturation on room air at rest ≤93%. partial pressure of oxygen in arterial blood/fio2 ≤300 mm hg. or critical if one of the following conditions is met. respiratory failure and mechanical ventilation are required. shock occurs another organ dysfunction is present risk of health complication >50% according to the health risk calculator less than 14 days of hospital discharge.