- with active tuberculosis, idiopathic pulmonary fibrosis, bronchial asthma, bronchiectasis, pulmonary embolism, patients with chronic respiratory failure or other severe respiratory disease; - according to the "pneumonia diagnosis and treatment program for new coronavirus infection" (trial version 6), critically ill patients - with severe patients with disease of heart head blood-vessel, malignant arrhythmia, unstable angina, acute myocardial infarction and death, cardiac function level 3 and above, stroke, cerebral hemorrhage, etc.); - with severe liver and kidney diseases (severe liver disease refers to cirrhosis, portal hypertension and varices bleeding, severe kidney disease including dialysis, kidney transplantation); - pregnant and lactating women; - severe cognitive and mental disorders; - clinical investigators who were participating in other interventions within 1 month prior to inclusion

- with active tuberculosis, idiopathic pulmonary fibrosis, bronchial asthma, bronchiectasis, pulmonary embolism, patients with chronic respiratory failure or other severe respiratory disease; - according to the "pneumonia diagnosis and treatment program for new coronavirus infection" (trial version 6), critically ill patients - with severe patients with disease of heart head blood-vessel, malignant arrhythmia, unstable angina, acute myocardial infarction and death, cardiac function level 3 and above, stroke, cerebral hemorrhage, etc.); - with severe liver and kidney diseases (severe liver disease refers to cirrhosis, portal hypertension and varices bleeding, severe kidney disease including dialysis, kidney transplantation); - pregnant and lactating women; - severe cognitive and mental disorders; - clinical investigators who were participating in other interventions within 1 month prior to inclusion