dementia, psychiatric or cognitive illness or recreational drug/alcohol use that in the opinion of the principle investigator, would affect subject safety and/or compliance. contraindication to transfusion or history of prior reactions to transfusion blood products. patients with selective iga deficiency. patients with mechanical ventilation and/or extracoporal membrane oxygenation (ecmo) at time of initial inclusion into the trial. mechanical ventilation is defined as either niv - non-invasive ventilation or positive pressure ventilation. enrollment into another clinical trial evaluating specific therapies for covid-19 is encouraged. participation in another trial with an investigational medicinal product. treatment with sars-cov-2 convalescent/vaccine-boosted plasma in the past.

dementia, psychiatric or cognitive illness or recreational drug/alcohol use that in the opinion of the principle investigator, would affect subject safety and/or compliance. contraindication to transfusion or history of prior reactions to transfusion blood products. patients with selective iga deficiency. patients with mechanical ventilation and/or extracoporal membrane oxygenation (ecmo) at time of initial inclusion into the trial. mechanical ventilation is defined as either niv - non-invasive ventilation or positive pressure ventilation. enrollment into another clinical trial evaluating specific therapies for covid-19 is encouraged. participation in another trial with an investigational medicinal product. treatment with sars-cov-2 convalescent/vaccine-boosted plasma in the past.