inclusion criteria: male or female adults who are between 18 and 60 years old inclusive weigh at least 45kg, with a bmi of 19 to 30 kg/m2 inclusive no serious underlying disease subjects should have normal (or abnormal but not clinically significant) laboratory results per the pi's judgement, including complete blood count, biochemistry, coagulation indices and urinalysis subjects should have a normal (or abnormal but not clinically significant) ecg and chest x-ray at screening current non-smokers and those who have not smoked within the last 6 months. this includes the use of cigarettes, e-cigarettes, and nicotine replacement products. female subjects should have negative results in serum pregnancy test at screening and negative urine pregnancy test at screening. agree to have no parenting plan during the study period and for 3 months after administration, and be able to use highly effective contraceptive measures, such as: complete abstinence (e.g. as the preferred lifestyle) intrauterine device (iud) female barrier method: cervical or uterine cap with spermicidal agent tubal sterilization vasectomy for male subjects or partners hormone-containing contraceptives levonorgestrel implant progesterone injection oral contrceptives (combined or progesterone alone) vaginal contraceptive ring transdermal contraceptive patch willing to cooperate and be able to participate in the study, comply with all requirements of the program, and sign informed consent. .

inclusion criteria: male or female adults who are between 18 and 60 years old inclusive weigh at least 45kg, with a bmi of 19 to 30 kg/m2 inclusive no serious underlying disease subjects should have normal (or abnormal but not clinically significant) laboratory results per the pi's judgement, including complete blood count, biochemistry, coagulation indices and urinalysis subjects should have a normal (or abnormal but not clinically significant) ecg and chest x-ray at screening current non-smokers and those who have not smoked within the last 6 months. this includes the use of cigarettes, e-cigarettes, and nicotine replacement products. female subjects should have negative results in serum pregnancy test at screening and negative urine pregnancy test at screening. agree to have no parenting plan during the study period and for 3 months after administration, and be able to use highly effective contraceptive measures, such as: complete abstinence (e.g. as the preferred lifestyle) intrauterine device (iud) female barrier method: cervical or uterine cap with spermicidal agent tubal sterilization vasectomy for male subjects or partners hormone-containing contraceptives levonorgestrel implant progesterone injection oral contrceptives (combined or progesterone alone) vaginal contraceptive ring transdermal contraceptive patch willing to cooperate and be able to participate in the study, comply with all requirements of the program, and sign informed consent. .

inclusion criteria: male or female adults who are between 18 and 60 years old inclusive weigh at least 45kg, with a bmi of 19 to 30 kg/m2 inclusive no serious underlying disease which would adversely affect the study conduct and data interpretation per the investigator subjects should have normal (or abnormal but not clinically significant) laboratory results per the pi's judgement, including complete blood count, biochemistry, coagulation indices and urinalysis subjects should have a normal (or abnormal but not clinically significant) ecg and chest x-ray at screening current non-smokers and those who have not smoked within the last 6 months. this includes the use of cigarettes, e-cigarettes, and nicotine replacement products. female subjects should have negative results in serum pregnancy test at screening and negative urine pregnancy test at admission. subjects of reproductive age and their partners agree to take effective contraceptive measures within 3 months after administration. note: no sex life, female barrier method: cervical cap or cervical cap with spermicide tubal sterilization male subject or partner undergo vasectomy hormonal contraceptives levonorgestrel implants progesterone injection oral contraceptives (combination or progesterone alone) vaginal contraceptive ring transdermal contraceptive patch willing to cooperate and be able to participate in the study, comply with all requirements of the program, and sign informed consent. .

inclusion criteria: male or female adults who are between 18 and 60 years old inclusive weigh at least 45kg, with a bmi of 19 to 30 kg/m2 inclusive no serious underlying disease which would adversely affect the study conduct and data interpretation per the investigator subjects should have normal (or abnormal but not clinically significant) laboratory results per the pi's judgement, including complete blood count, biochemistry, coagulation indices and urinalysis subjects should have a normal (or abnormal but not clinically significant) ecg and chest x-ray at screening current non-smokers and those who have not smoked within the last 6 months. this includes the use of cigarettes, e-cigarettes, and nicotine replacement products. female subjects should have negative results in serum pregnancy test at screening and negative urine pregnancy test at admission. subjects of reproductive age and their partners agree to take effective contraceptive measures within 3 months after administration. note: no sex life, female barrier method: cervical cap or cervical cap with spermicide tubal sterilization male subject or partner undergo vasectomy hormonal contraceptives levonorgestrel implants progesterone injection oral contraceptives (combination or progesterone alone) vaginal contraceptive ring transdermal contraceptive patch willing to cooperate and be able to participate in the study, comply with all requirements of the program, and sign informed consent. .