- if the attending clinician believes that there is a specific contra-indication to one of the active drug treatment arms (see protocol appendix 2; section 8.2 and appendix 3; section 8.3 for children) or that the patient should definitely be receiving one of the active drug treatment arms then that arm will not be available for randomisation for that patient. for patients who lack capacity, an advanced directive or behaviour that clearly indicates that they would not wish to participate in the trial would be considered sufficient reason to exclude them from the trial.

- if the attending clinician believes that there is a specific contra-indication to one of the active drug treatment arms (see protocol appendix 2; section 8.2 and appendix 3; section 8.3 for children) or that the patient should definitely be receiving one of the active drug treatment arms then that arm will not be available for randomisation for that patient. for patients who lack capacity, an advanced directive or behaviour that clearly indicates that they would not wish to participate in the trial would be considered sufficient reason to exclude them from the trial.