inclusion criteria: healthy age over 12 years the outcome of the following examinations should be clinically insignificant: medical and surgical history (hypo-, hypertension, allergy, other diseases, major surgery, micturition, defecation, sleep, illness within the last 4 weeks prior to the start of the trial); participant vaccinated with covid-19 over 6 months anti-sars cov 2 neutralizing antibody is negative in serum.

inclusion criteria: healthy age over 12 years the outcome of the following examinations should be clinically insignificant: medical and surgical history (hypo-, hypertension, allergy, other diseases, major surgery, micturition, defecation, sleep, illness within the last 4 weeks prior to the start of the trial); participant vaccinated with covid-19 over 6 months anti-sars cov 2 neutralizing antibody is negative in serum.