patients with proven hypersensitivity or allergic reaction to quercetin or curcumin patients with known chronic kidney disease with estimated creatinine clearance < 50 ml/minute or need for dialysis patients who are severely hypotensive defined as needing hemodynamic pressors to maintain blood pressure patients taking anticoagulant/antiplatelet drugs such as coumarine, heparine, aspirin, clopidrogel, dalteparin, enoxaparin, ticlopidine and warparin. patients with gallstone obstruction hypothyroid suppering patients patients with moderate or severe thrombocytopenia (platelet count <100 ×10⁹/l); pregnant patients

patients with proven hypersensitivity or allergic reaction to quercetin or curcumin patients with known chronic kidney disease with estimated creatinine clearance < 50 ml/minute or need for dialysis patients who are severely hypotensive defined as needing hemodynamic pressors to maintain blood pressure patients taking anticoagulant/antiplatelet drugs such as coumarine, heparine, aspirin, clopidrogel, dalteparin, enoxaparin, ticlopidine and warparin. patients with gallstone obstruction hypothyroid suppering patients patients with moderate or severe thrombocytopenia (platelet count <100 ×10⁹/l); pregnant patients