inclusion criteria: adults with age 18 to 50 years. willingness. for married females of childbearing age: willingness to practice continuous effective contraception for one year from the start of the study. agreement to refrain from blood donation during the study. body temperature is within the normal range (36.5 - 37.5°c). general good health as established by medical history, physical and laboratory examinations.

inclusion criteria: adults with age 18 to 50 years. willingness. for married females of childbearing age: willingness to practice continuous effective contraception for one year from the start of the study. agreement to refrain from blood donation during the study. body temperature is within the normal range (36.5 - 37.5°c). general good health as established by medical history, physical and laboratory examinations.