inclusion criteria: all individuals aged 18 to 65 years it has been confirmed positive for covid-19 by throat swab / sputum / brochoalveolar lavage (bal) with real-time reverse transcription polymerase chain reaction (rt-pcr) categorized as a severe case of covid-19 patient agree to participate and sign the informed consent

inclusion criteria: all individuals aged 18 to 65 years it has been confirmed positive for covid-19 by throat swab / sputum / brochoalveolar lavage (bal) with real-time reverse transcription polymerase chain reaction (rt-pcr) categorized as a severe case of covid-19 patient agree to participate and sign the informed consent