- - severe covid-19 pneumonia requiring invasive mechanical ventilation - creatinine clearance < 30 ml/min - end stage renal disease on hemodialysis - alt and/or ast > 5 upper limit of normal - pregnancy - lactation - to prevent colchicine toxicity, patients receiving a strong cyp3a4 inhibitor (eg clarithromycin, indinavir, itraconazole, ketoconazole, nefazodone, nelfinavir, ritonavir, saquinavir, telithromycin, atazanavir), a moderate cyp3a4 inhibitor (eg diltiazem, verapamil, fluconazole, amprenavir, aprepitant, fosamprenavir) or a p-gp inhibitor (eg cyclosporine, ranolazine), will be excluded

- - severe covid-19 pneumonia requiring invasive mechanical ventilation - creatinine clearance < 30 ml/min - end stage renal disease on hemodialysis - alt and/or ast > 5 upper limit of normal - pregnancy - lactation - to prevent colchicine toxicity, patients receiving a strong cyp3a4 inhibitor (eg clarithromycin, indinavir, itraconazole, ketoconazole, nefazodone, nelfinavir, ritonavir, saquinavir, telithromycin, atazanavir), a moderate cyp3a4 inhibitor (eg diltiazem, verapamil, fluconazole, amprenavir, aprepitant, fosamprenavir) or a p-gp inhibitor (eg cyclosporine, ranolazine), will be excluded