- patients admitted in intensive care within the first 6 hours of hospital care, - patients after 10 days from the start of symptoms - age < 18 years and > 90 years - long-term oxygen-dependent patients (at home), - decompensated chronic cardiac, respiratory, urological pathology - patient refusing administration of blood products, - allergic reaction to plasma products, - iga deficiency, - contraindication to transfusion - ig transfusion within 30 days, - patient currently participating to another clinical trial, - pregnant women, - no affiliated to the social security, - person deprived of liberty by a legal or administrative decision, person under guardianship

- patients admitted in intensive care within the first 6 hours of hospital care, - patients after 10 days from the start of symptoms - age < 18 years and > 90 years - long-term oxygen-dependent patients (at home), - decompensated chronic cardiac, respiratory, urological pathology - patient refusing administration of blood products, - allergic reaction to plasma products, - iga deficiency, - contraindication to transfusion - ig transfusion within 30 days, - patient currently participating to another clinical trial, - pregnant women, - no affiliated to the social security, - person deprived of liberty by a legal or administrative decision, person under guardianship

- patients admitted in intensive care within the first 6 hours of hospital care, - patients after 10 days from the start of symptoms - age < 18 years and > 80 years - long-term oxygen-dependent patients (at home), - decompensated chronic cardiac, respiratory, urological pathology - patient refusing administration of blood products, - allergic reaction to plasma products, - iga deficiency, - contraindication to transfusion - ig transfusion within 30 days, - patient currently participating to another clinical trial, - pregnant women, - no affiliated to the social security, - person deprived of liberty by a legal or administrative decision, person under guardianship

- patients admitted in intensive care within the first 6 hours of hospital care, - patients after 10 days from the start of symptoms - age < 18 years and > 80 years - long-term oxygen-dependent patients (at home), - decompensated chronic cardiac, respiratory, urological pathology - patient refusing administration of blood products, - allergic reaction to plasma products, - iga deficiency, - contraindication to transfusion - ig transfusion within 30 days, - patient currently participating to another clinical trial, - pregnant women, - no affiliated to the social security, - person deprived of liberty by a legal or administrative decision, person under guardianship