inclusion criteria: - participate in the clinical trial "nct05065879". - ≥60 years old individuals with full civil capacity. - clinically confirmed body temperature of <37.3°c before enrolling in this study. - able and willing to participate in the study plan during the entire study and follow-up period. - capable of understanding the study procedures, willing to sign the informed consent form, and able to comply with the requirements of the clinical study protocol. - inclusion criteria for patients with hypertension and/or diabetes: hypertension and/or diabetes definitively diagnosed by a community-level or higher medical institution. patients with hypertension: systolic pressure <160 mmhg and diastolic pressure <100 mmhg on the day of immunization achieved by lifestyle adjustment and/or drug treatment; patients with diabetes: fasting glucose ≤13.9 mmol/l on the day of (or within 3 days before) immunization achieved by lifestyle adjustment and/or drug treatment

inclusion criteria: - participate in the clinical trial "nct05065879". - ≥60 years old individuals with full civil capacity. - clinically confirmed body temperature of <37.3°c before enrolling in this study. - able and willing to participate in the study plan during the entire study and follow-up period. - capable of understanding the study procedures, willing to sign the informed consent form, and able to comply with the requirements of the clinical study protocol. - inclusion criteria for patients with hypertension and/or diabetes: hypertension and/or diabetes definitively diagnosed by a community-level or higher medical institution. patients with hypertension: systolic pressure <160 mmhg and diastolic pressure <100 mmhg on the day of immunization achieved by lifestyle adjustment and/or drug treatment; patients with diabetes: fasting glucose ≤13.9 mmol/l on the day of (or within 3 days before) immunization achieved by lifestyle adjustment and/or drug treatment