for all patients: - inability to decide to participate - pregnancy or breath feeding - hypersensitivity to any of the test drugs - stage 4 or 5 chronic kidney disease (dfg <30 ml/min/1.73 m²) for hydroxychloroquine arm: - long qt syndrome or qtc space >500 ms - treatment with piperazine, halofantrine, dasatinib, nilotinib, citalopram, escitalopram, hydroxyzine, domperidone - hepatic porphyria, retinopathy, known glucose-6-phosphate dehydrogenase deficiency, - heart rate <50/min - hypokaliemia < 3.5 mmol/l for diltiazem arm: - heart rate<40/min - sinus bradycardia, second- or third-degree atrioventricular block - left heart insufficiency with pulmonary stasis - treatment with dantrolene, pimozide, dihydroergotamine, ergotamine, nifedipine, ivabradine, esmolol, bêta-blockers (bisoprolol, carvedilol, metoprolol, nebivolol), fingolimod

for all patients: - inability to decide to participate - pregnancy or breath feeding - hypersensitivity to any of the test drugs - stage 4 or 5 chronic kidney disease (dfg <30 ml/min/1.73 m²) for hydroxychloroquine arm: - long qt syndrome or qtc space >500 ms - treatment with piperazine, halofantrine, dasatinib, nilotinib, citalopram, escitalopram, hydroxyzine, domperidone - hepatic porphyria, retinopathy, known glucose-6-phosphate dehydrogenase deficiency, - heart rate <50/min - hypokaliemia < 3.5 mmol/l for diltiazem arm: - heart rate<40/min - sinus bradycardia, second- or third-degree atrioventricular block - left heart insufficiency with pulmonary stasis - treatment with dantrolene, pimozide, dihydroergotamine, ergotamine, nifedipine, ivabradine, esmolol, bêta-blockers (bisoprolol, carvedilol, metoprolol, nebivolol), fingolimod