- lactose-intolerant patients - patient needing immediate hospitalization for any medical reason - patient having more than 5 days of clinical symptoms at the inclusion visit - patients with a history of allergy to tetracyclines - pregnant or lactating women - patients participating in another clinical trial - patients with photosensitive skin pathology - patients treated with anticoagulant - patients treated with oral retinoids: isotretinoin, alitretinoin, acitretin - patients treated with vitamin a patients treated with systemic antibiotics for the duration of treatment - patients treated with barbiturates, carbamazepine or phenytoin - patients with treatment that may have an effect on covid-19 infection: chloroquine, hydroxychloroquine, remdesivir, ganciclovir, acyclovir, ribavirin, lopinavir-ritonavir - patients under guardianship or trusteeship or in safeguard of justice

- lactose-intolerant patients - patient needing immediate hospitalization for any medical reason - patient having more than 5 days of clinical symptoms at the inclusion visit - patients with a history of allergy to tetracyclines - pregnant or lactating women - patients participating in another clinical trial - patients with photosensitive skin pathology - patients treated with anticoagulant - patients treated with oral retinoids: isotretinoin, alitretinoin, acitretin - patients treated with vitamin a patients treated with systemic antibiotics for the duration of treatment - patients treated with barbiturates, carbamazepine or phenytoin - patients with treatment that may have an effect on covid-19 infection: chloroquine, hydroxychloroquine, remdesivir, ganciclovir, acyclovir, ribavirin, lopinavir-ritonavir - patients under guardianship or trusteeship or in safeguard of justice