- pregnant or breastfeeding female - severe covid-19 requiring admission for inpatient treatment - need for any oxygen supplementation - need for mechanical ventilatory support - history of oxygen supplementation dependency - history of cancer with ongoing chemotherapy or radiation therapy - concurrent antimicrobial therapy - known hypersensitivity to hydroxychloroquine or other 4-aminoquinoline compounds - already taking hydroxychloroquine or chloroquine within 1 month - known g6-pd deficiency - history of retinopathy - history of current cardiac diseases (heart failure, ventricular arrhythmias, left bundle branch block and/or right bundle branch block, qtc prolongation >480ms), or family history of sudden cardiac death - ongoing use of drugs that prolong the qtc interval (antipsychotics, antidepressants, class i and iii antiarrhythmics, triptans) - severe renal disease: glomerular filtration rate (gfr) <30ml/min - severe hepatic impairment (elevated total bilirubin >2 mg/dl, decreased albumin <2.8 g/dl, signs of jaundice and ascites.) - active alcohol abuse (>5 drinks per day or >20 drinks per week.) - seizure disorder, currently on medications - known hypersensitivity to any tetracyclines.

- pregnant or breastfeeding female - severe covid-19 requiring admission for inpatient treatment - need for any oxygen supplementation - need for mechanical ventilatory support - history of oxygen supplementation dependency - history of cancer with ongoing chemotherapy or radiation therapy - concurrent antimicrobial therapy - known hypersensitivity to hydroxychloroquine or other 4-aminoquinoline compounds - already taking hydroxychloroquine or chloroquine within 1 month - known g6-pd deficiency - history of retinopathy - history of current cardiac diseases (heart failure, ventricular arrhythmias, left bundle branch block and/or right bundle branch block, qtc prolongation >480ms), or family history of sudden cardiac death - ongoing use of drugs that prolong the qtc interval (antipsychotics, antidepressants, class i and iii antiarrhythmics, triptans) - severe renal disease: glomerular filtration rate (gfr) <30ml/min - severe hepatic impairment (elevated total bilirubin >2 mg/dl, decreased albumin <2.8 g/dl, signs of jaundice and ascites.) - active alcohol abuse (>5 drinks per day or >20 drinks per week.) - seizure disorder, currently on medications - known hypersensitivity to any tetracyclines.