inclusion criteria: - sars-co-v2 positivity to the nasal-swab by reverse-transcriptase-polymerase chain- reaction (rt-pcr) assay tested by the local diagnostic laboratory - age >18 years - presence of any symptoms suggestive of covid-19, such as such as fever, fatigue, cough (with or without sputum production), shortness of breath, sore throat, nasal congestion, anorexia, malaise, or headache. rarely, patients may also present with diarrhea, nausea, and vomiting - presence of radiological findings of pneumonia assessed by chest radiograph, computed tomography - moderate and severe covid-19 as per previous definition national guideline/who - give informed written consent

inclusion criteria: - sars-co-v2 positivity to the nasal-swab by reverse-transcriptase-polymerase chain- reaction (rt-pcr) assay tested by the local diagnostic laboratory - age >18 years - presence of any symptoms suggestive of covid-19, such as such as fever, fatigue, cough (with or without sputum production), shortness of breath, sore throat, nasal congestion, anorexia, malaise, or headache. rarely, patients may also present with diarrhea, nausea, and vomiting - presence of radiological findings of pneumonia assessed by chest radiograph, computed tomography - moderate and severe covid-19 as per previous definition national guideline/who - give informed written consent