- a condition requiring invasive oxygen support; - history of hypersensitivity to budesonide and arformoterol - pregnancy, breast-feeding - participation in other clinical studies within 4 weeks prior to enrollment in this study. - refusal of the patient to continue participating in the study/withdrawal of informed consent by the patient.

- a condition requiring invasive oxygen support; - history of hypersensitivity to budesonide and arformoterol - pregnancy, breast-feeding - participation in other clinical studies within 4 weeks prior to enrollment in this study. - refusal of the patient to continue participating in the study/withdrawal of informed consent by the patient.