receiving oxygen supply before intervention known intolerance/allergy to the study drugs pregnancy sinus/oral operation within 30 days of the beginning of the study using intranasal medication before randomization no available informed consent inability to self-care or reply to questionnaire

receiving oxygen supply before intervention known intolerance/allergy to the study drugs pregnancy sinus/oral operation within 30 days of the beginning of the study using intranasal medication before randomization no available informed consent inability to self-care or reply to questionnaire

receiving oxygen supply before randomization known intolerance/allergy to the study drugs pregnancy sinus/oral operation within 30 days of the beginning of the study using intranasal medication before randomization no available informed consent inability to self-care or reply to questionnaire

receiving oxygen supply before randomization known intolerance/allergy to the study drugs pregnancy sinus/oral operation within 30 days of the beginning of the study using intranasal medication before randomization no available informed consent inability to self-care or reply to questionnaire

1. receiving oxygen supply before randomization 2. known intolerance/allergy to the study drugs 3. pregnancy 4. sinus/oral operation within 30 days of the beginning of the study 5. using intranasal medication before randomization 6. no available informed consent 7. inability to self-care or reply to questionnaire

1. receiving oxygen supply before randomization 2. known intolerance/allergy to the study drugs 3. pregnancy 4. sinus/oral operation within 30 days of the beginning of the study 5. using intranasal medication before randomization 6. no available informed consent 7. inability to self-care or reply to questionnaire