inclusion criteria: - able and willing to agree informed consent and aged 19 to 64 years. - the bmi index is 18.5 kg/m2 to 30.0 kg/m2. - able and willing to medically effective contraception during the whole study period. - agreement to refrain from blood donation during the whole study period.

inclusion criteria: - able and willing to agree informed consent and aged 19 to 64 years. - the bmi index is 18.5 kg/m2 to 30.0 kg/m2. - able and willing to medically effective contraception during the whole study period. - agreement to refrain from blood donation during the whole study period.