- have the medical history or family history of convulsion, epilepsy, encephalopathy and psychosis. - be allergic to any component of the research vaccines, or used to have a history of hypersensitivity or serious reactions to vaccination. - suffering from abnormal pulmonary function such as asthma, chronic obstructive pulmonary disease and pulmonary fibrosis. - suffering from more serious cardiovascular diseases, such as arrhythmia, conduction block, myocardial infarction, severe hypertension and uncontrollable medication. - have symptoms of upper respiratory tract infection. - women with positive urine pregnancy test, pregnant or breast-feeding, or have a pregnancy plan within six months. - have acute febrile diseases and infectious diseases. - have severe chronic diseases or condition in progress cannot be smoothly controlled, such as asthma, diabetes, thyroid disease - congenital or acquired angioedema / neuroedema. - have the history of urticaria 1 year before receiving the investigational vaccine. - have asplenia or functional asplenia. - have thrombocytopenia or other coagulation disorders (which may cause contraindications for intramuscular injection). - have needle sickness. - have the history of immunosuppressive therapy, anti-allergy therapy, cytotoxic therapy or inhaled corticosteroids (excluding corticosteroid spray therapy for allergic rhinitis, and acute corticosteroid therapy without dermatitis) over the past 6 months. - have received blood products within 4 months before injection of investigational vaccines. - have received another investigational product within one month before injection of investigational vaccine. - have received attenuated vaccine within 1 month before injection of investigational vaccine. - under anti-tuberculosis treatment. - not be able to follow the protocol, or not be able to understand the informed consent according to the researcher's judgment, due to various medical, psychological, social or other conditions.

- have the medical history or family history of convulsion, epilepsy, encephalopathy and psychosis. - be allergic to any component of the research vaccines, or used to have a history of hypersensitivity or serious reactions to vaccination. - suffering from abnormal pulmonary function such as asthma, chronic obstructive pulmonary disease and pulmonary fibrosis. - suffering from more serious cardiovascular diseases, such as arrhythmia, conduction block, myocardial infarction, severe hypertension and uncontrollable medication. - have symptoms of upper respiratory tract infection. - women with positive urine pregnancy test, pregnant or breast-feeding, or have a pregnancy plan within six months. - have acute febrile diseases and infectious diseases. - have severe chronic diseases or condition in progress cannot be smoothly controlled, such as asthma, diabetes, thyroid disease - congenital or acquired angioedema / neuroedema. - have the history of urticaria 1 year before receiving the investigational vaccine. - have asplenia or functional asplenia. - have thrombocytopenia or other coagulation disorders (which may cause contraindications for intramuscular injection). - have needle sickness. - have the history of immunosuppressive therapy, anti-allergy therapy, cytotoxic therapy or inhaled corticosteroids (excluding corticosteroid spray therapy for allergic rhinitis, and acute corticosteroid therapy without dermatitis) over the past 6 months. - have received blood products within 4 months before injection of investigational vaccines. - have received another investigational product within one month before injection of investigational vaccine. - have received attenuated vaccine within 1 month before injection of investigational vaccine. - under anti-tuberculosis treatment. - not be able to follow the protocol, or not be able to understand the informed consent according to the researcher's judgment, due to various medical, psychological, social or other conditions.