- history of drug reactions or allergies - pneumonia caused by bacteria, mycoplasma, chlamydia, legionella, fungi, or other viruses - airway obstruction due to lung cancer or unknown factors - carcinoid syndrome - history of epilepsy and long-term use of anticonvulsant drugs during the last 3 years - history of long-term use of immunosuppressive drugs - history of chronic respiratory illness that requires long-term oxygen therapy - the patient is on blood or peritoneal dialysis - creatinine clearance <15 ml / min - moderate to severe liver disease (child-pugh score> 12) - history of deep vein thrombosis (dvt) or pulmonary embolism over the past 3 years - being under ecmo or high-frequency oscillatory ventilation support - diagnostic of hiv, hepatitis b, and syphilis - pregnant or lactating women - lack of consciousness and inability to provide informed consent by the patient

- history of drug reactions or allergies - pneumonia caused by bacteria, mycoplasma, chlamydia, legionella, fungi, or other viruses - airway obstruction due to lung cancer or unknown factors - carcinoid syndrome - history of epilepsy and long-term use of anticonvulsant drugs during the last 3 years - history of long-term use of immunosuppressive drugs - history of chronic respiratory illness that requires long-term oxygen therapy - the patient is on blood or peritoneal dialysis - creatinine clearance <15 ml / min - moderate to severe liver disease (child-pugh score> 12) - history of deep vein thrombosis (dvt) or pulmonary embolism over the past 3 years - being under ecmo or high-frequency oscillatory ventilation support - diagnostic of hiv, hepatitis b, and syphilis - pregnant or lactating women - lack of consciousness and inability to provide informed consent by the patient