- people who are allergic to any component of the vaccine, or have a serious history of vaccine allergy. - women who is pregnant, breastfeeding, or planning to be pregnant within 6 months. - sufferring serious cardiovascular diseases, such as arrhythmia, conduction block, myocardial infarction, and severe hypertension can not be well controlled by drugs. - patients with severe chronic diseases or diseases can not be controlled well during the progress, such as asthma, diabetes, thyroid disease, etc. - patients with congenital or acquired angioedema / neuroedema. - patients with lymphoma, leukemia and other systemic malignancies. - patients with convulsions, epilepsy, encephalopathy, psychiatric disorders and other progressive neurological disorders, or a family history of them. - patients with acute attack of chronic diseases. - during vaccination, immunomodulators, systemic cytotoxic drugs, immune checkpoint inhibitors (pd-1 / pdl-1 / ctla-4, etc.) and cell therapy, including nk cells, cytokine induced killer cells, dendritic cells, ctl and stem cells infusion are required. - other conditions determined by the researcher.

- people who are allergic to any component of the vaccine, or have a serious history of vaccine allergy. - women who is pregnant, breastfeeding, or planning to be pregnant within 6 months. - sufferring serious cardiovascular diseases, such as arrhythmia, conduction block, myocardial infarction, and severe hypertension can not be well controlled by drugs. - patients with severe chronic diseases or diseases can not be controlled well during the progress, such as asthma, diabetes, thyroid disease, etc. - patients with congenital or acquired angioedema / neuroedema. - patients with lymphoma, leukemia and other systemic malignancies. - patients with convulsions, epilepsy, encephalopathy, psychiatric disorders and other progressive neurological disorders, or a family history of them. - patients with acute attack of chronic diseases. - during vaccination, immunomodulators, systemic cytotoxic drugs, immune checkpoint inhibitors (pd-1 / pdl-1 / ctla-4, etc.) and cell therapy, including nk cells, cytokine induced killer cells, dendritic cells, ctl and stem cells infusion are required. - other conditions determined by the researcher.