- patient with pre-existing respiratory disease (cancer, copd, asthma, emphysema) or smoking history of > 25 years) - patient with a known allergy to one of the study products - patient treated with anti tnf, il1 or il6 - patient requiring immediate intubation - patient on a low sodium diet - patient under protective custody, guardianship or trusteeship - patient not affiliated to the french social security system - patient participating in another therapeutic protocol - pregnant or likely to become pregnant (woman of childbearing age without effective contraception and without hcg dosage) - patient unable to understand informed information and/or give written informed consent: dementia, psychosis, consciousness disorders, non-french speaking patient

- patient with pre-existing respiratory disease (cancer, copd, asthma, emphysema) or smoking history of > 25 years) - patient with a known allergy to one of the study products - patient treated with anti tnf, il1 or il6 - patient requiring immediate intubation - patient on a low sodium diet - patient under protective custody, guardianship or trusteeship - patient not affiliated to the french social security system - patient participating in another therapeutic protocol - pregnant or likely to become pregnant (woman of childbearing age without effective contraception and without hcg dosage) - patient unable to understand informed information and/or give written informed consent: dementia, psychosis, consciousness disorders, non-french speaking patient