- patients with proven hypersensitivity or allergic reaction to quercetin or curcumin - patients with known chronic kidney disease with estimated creatinine clearance < 50 ml/minute or need for dialysis - patients who are severely hypotensive defined as needing hemodynamic pressors to maintain blood pressure - patients taking anticoagulant/antiplatelet drugs such as coumarine, heparine, aspirin, clopidrogel, dalteparin, enoxaparin, ticlopidine and warparin. - patients with gallstone obstruction - hypothyroid suppering patients - patients with moderate or severe thrombocytopenia (platelet count <100 ×10⁹/l); - pregnant patients

- patients with proven hypersensitivity or allergic reaction to quercetin or curcumin - patients with known chronic kidney disease with estimated creatinine clearance < 50 ml/minute or need for dialysis - patients who are severely hypotensive defined as needing hemodynamic pressors to maintain blood pressure - patients taking anticoagulant/antiplatelet drugs such as coumarine, heparine, aspirin, clopidrogel, dalteparin, enoxaparin, ticlopidine and warparin. - patients with gallstone obstruction - hypothyroid suppering patients - patients with moderate or severe thrombocytopenia (platelet count <100 ×10⁹/l); - pregnant patients