inclusion criteria: - participant must be 18 years of age and older, at the time of signing the informed consent; - participants who are healthy or medically stable as determined by medical evaluation including medical history, physical examination, clinical laboratory tests, and medical judgement of the investigator; - participants who are able to attend all scheduled visits and comply with all study procedures; - female participants of childbearing potential must agree to be heterosexually inactive, or agree to consistently use at least one acceptable method of contraception from at least 4 weeks prior to the 1st study vaccination to 12 weeks after the last study vaccination; - female participants with a negative urine or serum pregnancy test at screening; - capable of giving signed informed consent which includes compliance with the requirements and restrictions listed in the informed consent form (icf) and in protocol;

inclusion criteria: - participant must be 18 years of age and older, at the time of signing the informed consent; - participants who are healthy or medically stable as determined by medical evaluation including medical history, physical examination, clinical laboratory tests, and medical judgement of the investigator; - participants who are able to attend all scheduled visits and comply with all study procedures; - female participants of childbearing potential must agree to be heterosexually inactive, or agree to consistently use at least one acceptable method of contraception from at least 4 weeks prior to the 1st study vaccination to 12 weeks after the last study vaccination; - female participants with a negative urine or serum pregnancy test at screening; - capable of giving signed informed consent which includes compliance with the requirements and restrictions listed in the informed consent form (icf) and in protocol;