- 1. concomitant participation in another clinical trial. 2. hypersensitivity to colchicine 3. pregnancy and lactation 4. over 70 years 5. kidney failure with creatinine clearance <30 ml / min. 6. known liver failure 7. concomitant medication that has interactions with colchicine and that due to its indication cannot be suspended or substituted

- 1. concomitant participation in another clinical trial. 2. hypersensitivity to colchicine 3. pregnancy and lactation 4. over 70 years 5. kidney failure with creatinine clearance <30 ml / min. 6. known liver failure 7. concomitant medication that has interactions with colchicine and that due to its indication cannot be suspended or substituted