- invasive mechanical ventilation - i.v. hydratation with darrow's solution or half-strength darrow's solution underway - acute cardiovascular event (acute myocardial infarction, acute ischaemic stroke) - current malignant disease - creatinine >1.8 mg/dl (for women) and >2.0 mg/dl (for men) or glomerular filtration rate <50 ml/mm - systolic blood pressure <110 mmhg and/or diastolic blood pressure <60 mmhg - known or suspected hypersensitivity to canrenone - hyponatremia - anuria - familial history of porphyria - pregnancy and breastfeeding - known or suspected hypersensitivity to canrenone - inclusion in any other pharmacological clinical trials

- invasive mechanical ventilation - i.v. hydratation with darrow's solution or half-strength darrow's solution underway - acute cardiovascular event (acute myocardial infarction, acute ischaemic stroke) - current malignant disease - creatinine >1.8 mg/dl (for women) and >2.0 mg/dl (for men) or glomerular filtration rate <50 ml/mm - systolic blood pressure <110 mmhg and/or diastolic blood pressure <60 mmhg - known or suspected hypersensitivity to canrenone - hyponatremia - anuria - familial history of porphyria - pregnancy and breastfeeding - known or suspected hypersensitivity to canrenone - inclusion in any other pharmacological clinical trials