inclusion criteria : group 1 salaried staff of the georges-françois leclerc center over 18 years old subject vaccinated against sars-cov-2 for at least 1 month (last injection), and less than 4 months (last injection). subject who gave his consent to this study subject affiliated to a social security scheme group 2 salaried staff of the georges françois leclerc center over 18 years old subject not vaccinated against sars-cov-2 subject having presented a proven infection by sars-cov-2 (pcr) subject who participated in the canserocov study with a positive serology result subject who gave his consent to this study subject affiliated to a social security scheme group 3 patient over 18 years of age treated in oncology at the gf leclerc center for: metastatic colorectal cancer beyond the first line of treatment metastatic pancreatic cancer as the first line of treatment metastatic breast cancer treated with anti-cdk4 / 6 + hormone therapy, or localized breast cancer treated with (neo) adjuvant chemotherapy patient vaccinated against sars-cov-2 for at least 1 month (last injection), and less than 4 months (last injection) with a vaccination performed when the anti-cancer treatment had been started for at least 1 month (last injection) ) (see diagram below) patient having signed the informed consent for the study patient affiliated to the social security scheme

inclusion criteria : group 1 salaried staff of the georges-françois leclerc center over 18 years old subject vaccinated against sars-cov-2 for at least 1 month (last injection), and less than 4 months (last injection). subject who gave his consent to this study subject affiliated to a social security scheme group 2 salaried staff of the georges françois leclerc center over 18 years old subject not vaccinated against sars-cov-2 subject having presented a proven infection by sars-cov-2 (pcr) subject who participated in the canserocov study with a positive serology result subject who gave his consent to this study subject affiliated to a social security scheme group 3 patient over 18 years of age treated in oncology at the gf leclerc center for: metastatic colorectal cancer beyond the first line of treatment metastatic pancreatic cancer as the first line of treatment metastatic breast cancer treated with anti-cdk4 / 6 + hormone therapy, or localized breast cancer treated with (neo) adjuvant chemotherapy patient vaccinated against sars-cov-2 for at least 1 month (last injection), and less than 4 months (last injection) with a vaccination performed when the anti-cancer treatment had been started for at least 1 month (last injection) ) (see diagram below) patient having signed the informed consent for the study patient affiliated to the social security scheme

inclusion criteria : group 1 1. salaried staff of the georges-françois leclerc center over 18 years old 2. subject vaccinated against sars-cov-2 for at least 1 month (last injection), and less than 4 months (last injection). 3. subject who gave his consent to this study 4. subject affiliated to a social security scheme group 2 1. salaried staff of the georges françois leclerc center over 18 years old 2. subject not vaccinated against sars-cov-2 3. subject having presented a proven infection by sars-cov-2 (pcr) 4. subject who participated in the canserocov study with a positive serology result 5. subject who gave his consent to this study 6. subject affiliated to a social security scheme group 3 1. patient over 18 years of age treated in oncology at the gf leclerc center for: - metastatic colorectal cancer beyond the first line of treatment - metastatic pancreatic cancer as the first line of treatment - metastatic breast cancer treated with anti-cdk4 / 6 + hormone therapy, or localized breast cancer treated with (neo) adjuvant chemotherapy 2. patient vaccinated against sars-cov-2 for at least 1 month (last injection), and less than 4 months (last injection) with a vaccination performed when the anti-cancer treatment had been started for at least 1 month (last injection) ) (see diagram below) 3. patient having signed the informed consent for the study 4. patient affiliated to the social security scheme

inclusion criteria : group 1 1. salaried staff of the georges-françois leclerc center over 18 years old 2. subject vaccinated against sars-cov-2 for at least 1 month (last injection), and less than 4 months (last injection). 3. subject who gave his consent to this study 4. subject affiliated to a social security scheme group 2 1. salaried staff of the georges françois leclerc center over 18 years old 2. subject not vaccinated against sars-cov-2 3. subject having presented a proven infection by sars-cov-2 (pcr) 4. subject who participated in the canserocov study with a positive serology result 5. subject who gave his consent to this study 6. subject affiliated to a social security scheme group 3 1. patient over 18 years of age treated in oncology at the gf leclerc center for: - metastatic colorectal cancer beyond the first line of treatment - metastatic pancreatic cancer as the first line of treatment - metastatic breast cancer treated with anti-cdk4 / 6 + hormone therapy, or localized breast cancer treated with (neo) adjuvant chemotherapy 2. patient vaccinated against sars-cov-2 for at least 1 month (last injection), and less than 4 months (last injection) with a vaccination performed when the anti-cancer treatment had been started for at least 1 month (last injection) ) (see diagram below) 3. patient having signed the informed consent for the study 4. patient affiliated to the social security scheme