- subjects who has not signed informed consent forms - subjects included in another clinical trial. - subjects under treatment with immunosuppressants. - subjects in treatment with another type of immunotherapy. - subjects who are or have been undergoing treatment with metformin. - subjects who are or have been treated with statins. - subjects who are or have been under treatment with sertraline. - pregnant women. - subjects who cannot offer cooperation and / or have serious psychiatric disorders. -subjects who are allergic to any of the components of bactek-r (mv130). - subjects with pathologies described in the charlson index

- subjects who has not signed informed consent forms - subjects included in another clinical trial. - subjects under treatment with immunosuppressants. - subjects in treatment with another type of immunotherapy. - subjects who are or have been undergoing treatment with metformin. - subjects who are or have been treated with statins. - subjects who are or have been under treatment with sertraline. - pregnant women. - subjects who cannot offer cooperation and / or have serious psychiatric disorders. -subjects who are allergic to any of the components of bactek-r (mv130). - subjects with pathologies described in the charlson index

1. - subjects who has not signed informed consent forms 2. - subjects included in another clinical trial. 3. - subjects under treatment with immunosuppressants. 4. - subjects in treatment with another type of immunotherapy. 5. - subjects who are or have been undergoing treatment with metformin. 6. - subjects who are or have been treated with statins. 7. - subjects who are or have been under treatment with sertraline. 8. - pregnant women. 9. - subjects who cannot offer cooperation and / or have serious psychiatric disorders. 10. -subjects who are allergic to any of the components of bactek-r (mv130). 11. - subjects with pathologies described in the charlson index

1. - subjects who has not signed informed consent forms 2. - subjects included in another clinical trial. 3. - subjects under treatment with immunosuppressants. 4. - subjects in treatment with another type of immunotherapy. 5. - subjects who are or have been undergoing treatment with metformin. 6. - subjects who are or have been treated with statins. 7. - subjects who are or have been under treatment with sertraline. 8. - pregnant women. 9. - subjects who cannot offer cooperation and / or have serious psychiatric disorders. 10. -subjects who are allergic to any of the components of bactek-r (mv130). 11. - subjects with pathologies described in the charlson index