- known valvular heart defects, pulmonary hypertension or heart failure - known to have cystic fibrosis - gi fistula or malabsorption syndrome - known allergy to ampicillin, clindamycin and imipenem - any other condition which, in the opinion of the investigator, would prevent full participation in the study or would interfere with the evaluation of the study endpoints - antibiotic treatment at enrolment or within 2 days prior - pregnant or breastfeeding females - unable or unwilling to follow contraception requirements - concurrent participation in another interventional clinical trial at enrolment or within 30 days prior

- known valvular heart defects, pulmonary hypertension or heart failure - known to have cystic fibrosis - gi fistula or malabsorption syndrome - known allergy to ampicillin, clindamycin and imipenem - any other condition which, in the opinion of the investigator, would prevent full participation in the study or would interfere with the evaluation of the study endpoints - antibiotic treatment at enrolment or within 2 days prior - pregnant or breastfeeding females - unable or unwilling to follow contraception requirements - concurrent participation in another interventional clinical trial at enrolment or within 30 days prior