inclusion criteria: - population at risk of developing severe covid-19, defined as either: - age ≥ 40 years - age ≥ 18 years and at least one of the following comorbidities: chronic heart disease without heart failure or proarrhythmic conditions or ventricular arrythmias, diabetes, chronic lung disease, hypertension, chronic kidney disease estimated glomerula filtration rate (gfr)<60 ml/minute, bmi - 30 kg/m2. - covid-19 disease confirmed by the presence of sars-cov-2 nucleic acid by polymerase chain reaction (pcr) within 5 days prior to inclusion. - for women of childbearing age (defined as non-sterile premenopausal women): negative pregnancy test and willingness to use contraceptive during the study period (90 days) ● provision of informed consent.

inclusion criteria: - population at risk of developing severe covid-19, defined as either: - age ≥ 40 years - age ≥ 18 years and at least one of the following comorbidities: chronic heart disease without heart failure or proarrhythmic conditions or ventricular arrythmias, diabetes, chronic lung disease, hypertension, chronic kidney disease estimated glomerula filtration rate (gfr)<60 ml/minute, bmi - 30 kg/m2. - covid-19 disease confirmed by the presence of sars-cov-2 nucleic acid by polymerase chain reaction (pcr) within 5 days prior to inclusion. - for women of childbearing age (defined as non-sterile premenopausal women): negative pregnancy test and willingness to use contraceptive during the study period (90 days) ● provision of informed consent.

inclusion criteria: - population at risk of developing severe covid-19, defined as either: - age ≥ 50 years - age ≥ 18 years and at least one of the following comorbidities: chronic heart disease without heart failure or proarrhythmic conditions or ventricular arrythmias, diabetes, chronic lung disease, hypertension, chronic kidney disease estimated glomerula filtration rate (gfr)<60 ml/minute, bmi - 30 kg/m2. - covid-19 disease confirmed by the presence of sars-cov-2 nucleic acid by polymerase chain reaction (pcr) within 5 days prior to inclusion. - for women of childbearing age (defined as non-sterile premenopausal women): negative pregnancy test and willingness to use contraceptive during the study period (90 days) ● provision of informed consent.

inclusion criteria: - population at risk of developing severe covid-19, defined as either: - age ≥ 50 years - age ≥ 18 years and at least one of the following comorbidities: chronic heart disease without heart failure or proarrhythmic conditions or ventricular arrythmias, diabetes, chronic lung disease, hypertension, chronic kidney disease estimated glomerula filtration rate (gfr)<60 ml/minute, bmi - 30 kg/m2. - covid-19 disease confirmed by the presence of sars-cov-2 nucleic acid by polymerase chain reaction (pcr) within 5 days prior to inclusion. - for women of childbearing age (defined as non-sterile premenopausal women): negative pregnancy test and willingness to use contraceptive during the study period (90 days) ● provision of informed consent.

inclusion criteria: - population at risk of developing severe covid-19, defined as either: - age ≥ 50 years - age ≥ 18 years and at least one of the following comorbidities: chronic heart disease without heart failure or proarrhythmic conditions or ventricular arrythmias, diabetes, chronic lung disease, hypertension, chronic kidney disease gfr<60 ml/minute, bmi - 30 kg/m2. - covid-19 disease confirmed by the presence of sars-cov-2 nucleic acid by polymerase chain reaction (pcr) within 5 days prior to inclusion. - for women of childbearing age (defined as non-sterile premenopausal women): negative pregnancy test and willingness to use contraceptive during the study period (90 days) ● provision of informed consent.

inclusion criteria: - population at risk of developing severe covid-19, defined as either: - age ≥ 50 years - age ≥ 18 years and at least one of the following comorbidities: chronic heart disease without heart failure or proarrhythmic conditions or ventricular arrythmias, diabetes, chronic lung disease, hypertension, chronic kidney disease gfr<60 ml/minute, bmi - 30 kg/m2. - covid-19 disease confirmed by the presence of sars-cov-2 nucleic acid by polymerase chain reaction (pcr) within 5 days prior to inclusion. - for women of childbearing age (defined as non-sterile premenopausal women): negative pregnancy test and willingness to use contraceptive during the study period (90 days) ● provision of informed consent.