- patient hospitalized in intensive care unit, - patient who received more than 24 hours of antibiotic treatment for the ongoing episode, - chronic renal failure with a glomerular filtration rate < 20ml/min, - severe hepatic failure, - severe chronic cardiac insufficiency, - allergy to macrolides, - electrocardiogram showing corrected qt prolongation greater than 470 ms in men and 480 ms in women. - life-threatening presentation expected to lead to possible imminent death (based on provider assessment)

- patient hospitalized in intensive care unit, - patient who received more than 24 hours of antibiotic treatment for the ongoing episode, - chronic renal failure with a glomerular filtration rate < 20ml/min, - severe hepatic failure, - severe chronic cardiac insufficiency, - allergy to macrolides, - electrocardiogram showing corrected qt prolongation greater than 470 ms in men and 480 ms in women. - life-threatening presentation expected to lead to possible imminent death (based on provider assessment)