- - severe covid-19 defined as news-2 score >5 or admission to the icu needing ventilation or pressure support. - contra-indications for hydroxychloroquine or chloroquine - unable to take oral medication (chloroquine and hydroxychloroquine can be administered through tube feeding which is considered oral administration) - identified allergies to 4-aminoquinoline - severe diseases of the blood system - 6-phosphate dehydrogenase deficiency - history of acute myocardial infarction, unstable angina pectoris, severe arrhythmia (frequent ventricular, ventricular tachycardia, ventricular fibrillation) in recent 6 months; new york heart association (nyha) level iii-iv - known corrected qt interval (qtc) ≥ 500ms. - uncorrected severe hypokalaemia (< 2,5 mmol/l) or uncorrected severe hypomagnesemia (< 0.6 mmol/l) - pancreatitis - refusal to participate expressed by patient or legally authorized representative if they are present

- - severe covid-19 defined as news-2 score >5 or admission to the icu needing ventilation or pressure support. - contra-indications for hydroxychloroquine or chloroquine - unable to take oral medication (chloroquine and hydroxychloroquine can be administered through tube feeding which is considered oral administration) - identified allergies to 4-aminoquinoline - severe diseases of the blood system - 6-phosphate dehydrogenase deficiency - history of acute myocardial infarction, unstable angina pectoris, severe arrhythmia (frequent ventricular, ventricular tachycardia, ventricular fibrillation) in recent 6 months; new york heart association (nyha) level iii-iv - known corrected qt interval (qtc) ≥ 500ms. - uncorrected severe hypokalaemia (< 2,5 mmol/l) or uncorrected severe hypomagnesemia (< 0.6 mmol/l) - pancreatitis - refusal to participate expressed by patient or legally authorized representative if they are present