inclusion criteria - confirmed covid-19 patients by rt-pcr - clinically suspected covid-19 patients - age > 18 years - patients requiring oxygen at least> 5l/min up to 15 l/min (by fm/ nrm)to maintain saturation >92% to 96% note: clinically suspected covid-19 = fever (temperature >37.8 degree celsius) + respiratory symptoms + radiological evidences exclusion criteria - multi-organ failure - severe ards (requiring hfnc orventilatory support on presentation in the form ofinvasive or non-invasive ventilation) - septic shock - severe liver disease - acute heart failure - acute kidney injury (where gfr< 15 and plasma-sulfamethoxazoleconcentration cannot be monitored) - drug allergy/intolerance to co-trimoxazole / sulphar sensitivity - pregnancy

inclusion criteria - confirmed covid-19 patients by rt-pcr - clinically suspected covid-19 patients - age > 18 years - patients requiring oxygen at least> 5l/min up to 15 l/min (by fm/ nrm)to maintain saturation >92% to 96% note: clinically suspected covid-19 = fever (temperature >37.8 degree celsius) + respiratory symptoms + radiological evidences exclusion criteria - multi-organ failure - severe ards (requiring hfnc orventilatory support on presentation in the form ofinvasive or non-invasive ventilation) - septic shock - severe liver disease - acute heart failure - acute kidney injury (where gfr< 15 and plasma-sulfamethoxazoleconcentration cannot be monitored) - drug allergy/intolerance to co-trimoxazole / sulphar sensitivity - pregnancy