inclusion criteria: age ≥18 years or the legal age of consent in the jurisdiction in which the trial is taking place at the time of signing the informed consent hospitalized due to severe acute respiratory syndrome coronavirus-2 (sars-cov-2) infection confirmed by polymerase chain reaction test, documented by either of the following: polymerase chain reaction (pcr) positive in sample collected <72 hours prior to randomization (visit 2); or pcr positive in sample collected ≥72 hours and ≤7 days prior to randomization, documented inability to obtain a repeat sample and progressive disease suggestive of ongoing sars-cov-2 infection a score of 5 or 6 on the 8-point ordinal scale: score 5: hospitalized, requiring supplemental oxygen score 6: hospitalized, on non-invasive ventilation or high-flow oxygen device contraceptive use by men and women of childbearing potential consistent with local regulations regarding the methods of contraception for those participating in clinical studies written informed consent, consistent with international council for harmonization good clinical practice revision 2 and local laws, obtained before the initiation of any trial- related procedure capable of giving signed informed consent which includes compliance with the requirements and restrictions listed in the informed consent form and in this protocol

inclusion criteria: age ≥18 years or the legal age of consent in the jurisdiction in which the trial is taking place at the time of signing the informed consent hospitalized due to severe acute respiratory syndrome coronavirus-2 (sars-cov-2) infection confirmed by polymerase chain reaction test, documented by either of the following: polymerase chain reaction (pcr) positive in sample collected <72 hours prior to randomization (visit 2); or pcr positive in sample collected ≥72 hours and ≤7 days prior to randomization, documented inability to obtain a repeat sample and progressive disease suggestive of ongoing sars-cov-2 infection a score of 5 or 6 on the 8-point ordinal scale: score 5: hospitalized, requiring supplemental oxygen score 6: hospitalized, on non-invasive ventilation or high-flow oxygen device contraceptive use by men and women of childbearing potential consistent with local regulations regarding the methods of contraception for those participating in clinical studies written informed consent, consistent with international council for harmonization good clinical practice revision 2 and local laws, obtained before the initiation of any trial- related procedure capable of giving signed informed consent which includes compliance with the requirements and restrictions listed in the informed consent form and in this protocol

inclusion criteria: 1. age ≥18 years or the legal age of consent in the jurisdiction in which the trial is taking place at the time of signing the informed consent 2. hospitalized due to severe acute respiratory syndrome coronavirus-2 (sars-cov-2) infection confirmed by polymerase chain reaction test, documented by either of the following: 1. polymerase chain reaction (pcr) positive in sample collected <72 hours prior to randomization (visit 2); or 2. pcr positive in sample collected ≥72 hours and ≤7 days prior to randomization, documented inability to obtain a repeat sample and progressive disease suggestive of ongoing sars-cov-2 infection 3. a score of 5 or 6 on the 8-point ordinal scale: 1. score 5: hospitalized, requiring supplemental oxygen 2. score 6: hospitalized, on non-invasive ventilation or high-flow oxygen device 4. contraceptive use by men and women of childbearing potential consistent with local regulations regarding the methods of contraception for those participating in clinical studies 5. written informed consent, consistent with international council for harmonization good clinical practice revision 2 and local laws, obtained before the initiation of any trial- related procedure 6. capable of giving signed informed consent which includes compliance with the requirements and restrictions listed in the informed consent form and in this protocol

inclusion criteria: 1. age ≥18 years or the legal age of consent in the jurisdiction in which the trial is taking place at the time of signing the informed consent 2. hospitalized due to severe acute respiratory syndrome coronavirus-2 (sars-cov-2) infection confirmed by polymerase chain reaction test, documented by either of the following: 1. polymerase chain reaction (pcr) positive in sample collected <72 hours prior to randomization (visit 2); or 2. pcr positive in sample collected ≥72 hours and ≤7 days prior to randomization, documented inability to obtain a repeat sample and progressive disease suggestive of ongoing sars-cov-2 infection 3. a score of 5 or 6 on the 8-point ordinal scale: 1. score 5: hospitalized, requiring supplemental oxygen 2. score 6: hospitalized, on non-invasive ventilation or high-flow oxygen device 4. contraceptive use by men and women of childbearing potential consistent with local regulations regarding the methods of contraception for those participating in clinical studies 5. written informed consent, consistent with international council for harmonization good clinical practice revision 2 and local laws, obtained before the initiation of any trial- related procedure 6. capable of giving signed informed consent which includes compliance with the requirements and restrictions listed in the informed consent form and in this protocol