critical disease, defined by need for mechanical ventilation expected death within 48 hours patients taking any of the following for chronic inflammatory diseases: glucocorticoids equivalent to prednisone > 10 mg/day (methylprednisolone > 8 mg/day, dexamethasone > 2 mg/day), a jak inhibitor (tofacitinib, baricitinib, upadacitinib), or a biologic use of chronic inhaled steroids is not an exclusion current or recent short-term use of glucocorticoids for chronic conditions such as copd or gout is not an exclusion. current use of glucocorticoids for covid-19 is not an exclusion use of biologics for non-inflammatory diseases is not an exclusion receipt of any il-6 inhibitor within 3 months prior to enrollment in the trial pregnancy, due to lack of fetal monitoring capabilities patients enrolled in other interventional clinical trials, including for covid-19. patients enrolled in non-interventional studies or receiving non-fda-approved drugs for compassionate use are not excluded. patients whose goal of care is comfort measures only inability to provide informed consent, or absence of a legally authorized representative to provide informed consent. severe psychiatric disease that prevents compliance with typical medical care. initial positive test for active infection with novel coronavirus sars-cov-2019 was >4 weeks prior to current admission.

critical disease, defined by need for mechanical ventilation expected death within 48 hours patients taking any of the following for chronic inflammatory diseases: glucocorticoids equivalent to prednisone > 10 mg/day (methylprednisolone > 8 mg/day, dexamethasone > 2 mg/day), a jak inhibitor (tofacitinib, baricitinib, upadacitinib), or a biologic use of chronic inhaled steroids is not an exclusion current or recent short-term use of glucocorticoids for chronic conditions such as copd or gout is not an exclusion. current use of glucocorticoids for covid-19 is not an exclusion use of biologics for non-inflammatory diseases is not an exclusion receipt of any il-6 inhibitor within 3 months prior to enrollment in the trial pregnancy, due to lack of fetal monitoring capabilities patients enrolled in other interventional clinical trials, including for covid-19. patients enrolled in non-interventional studies or receiving non-fda-approved drugs for compassionate use are not excluded. patients whose goal of care is comfort measures only inability to provide informed consent, or absence of a legally authorized representative to provide informed consent. severe psychiatric disease that prevents compliance with typical medical care. initial positive test for active infection with novel coronavirus sars-cov-2019 was >4 weeks prior to current admission.

1. critical disease, defined by need for mechanical ventilation 2. expected death within 48 hours 3. patients taking any of the following for chronic inflammatory diseases: glucocorticoids equivalent to prednisone > 10 mg/day (methylprednisolone > 8 mg/day, dexamethasone > 2 mg/day), a jak inhibitor (tofacitinib, baricitinib, upadacitinib), or a biologic 1. use of chronic inhaled steroids is not an exclusion 2. current or recent short-term use of glucocorticoids for chronic conditions such as copd or gout is not an exclusion. 3. current use of glucocorticoids for covid-19 is not an exclusion 4. use of biologics for non-inflammatory diseases is not an exclusion 4. receipt of any il-6 inhibitor within 3 months prior to enrollment in the trial 5. pregnancy, due to lack of fetal monitoring capabilities 6. patients enrolled in other interventional clinical trials, including for covid-19. patients enrolled in non-interventional studies or receiving non-fda-approved drugs for compassionate use are not excluded. 7. patients whose goal of care is comfort measures only 8. inability to provide informed consent, or absence of a legally authorized representative to provide informed consent. 9. severe psychiatric disease that prevents compliance with typical medical care. 10. initial positive test for active infection with novel coronavirus sars-cov-2019 was >4 weeks prior to current admission.

1. critical disease, defined by need for mechanical ventilation 2. expected death within 48 hours 3. patients taking any of the following for chronic inflammatory diseases: glucocorticoids equivalent to prednisone > 10 mg/day (methylprednisolone > 8 mg/day, dexamethasone > 2 mg/day), a jak inhibitor (tofacitinib, baricitinib, upadacitinib), or a biologic 1. use of chronic inhaled steroids is not an exclusion 2. current or recent short-term use of glucocorticoids for chronic conditions such as copd or gout is not an exclusion. 3. current use of glucocorticoids for covid-19 is not an exclusion 4. use of biologics for non-inflammatory diseases is not an exclusion 4. receipt of any il-6 inhibitor within 3 months prior to enrollment in the trial 5. pregnancy, due to lack of fetal monitoring capabilities 6. patients enrolled in other interventional clinical trials, including for covid-19. patients enrolled in non-interventional studies or receiving non-fda-approved drugs for compassionate use are not excluded. 7. patients whose goal of care is comfort measures only 8. inability to provide informed consent, or absence of a legally authorized representative to provide informed consent. 9. severe psychiatric disease that prevents compliance with typical medical care. 10. initial positive test for active infection with novel coronavirus sars-cov-2019 was >4 weeks prior to current admission.

1. critical disease, defined by need for mechanical ventilation and/or icu admission 2. expected death within 48 hours 3. patients currently taking prednisone > 10 mg/day or on treatment with biologics for chronic inflammatory diseases a. use of chronic inhaled steroids is not an exclusion 4. receipt of any il-6 inhibitor within 3 months prior to enrollment in the trial 5. pregnancy, due to lack of fetal monitoring capabilities 6. patients enrolled in other interventional clinical trials. patients enrolled in non-interventional studies or receiving non-fda-approved drugs for compassionate use are not excluded. 7. patients whose goal of care is comfort measures only 8. inability to provide informed consent, or absence of a legally authorized representative to provide informed consent. 9. severe psychiatric disease that prevents compliance with typical medical care. 10. participation in another interventional clinical trial for covid-19

1. critical disease, defined by need for mechanical ventilation and/or icu admission 2. expected death within 48 hours 3. patients currently taking prednisone > 10 mg/day or on treatment with biologics for chronic inflammatory diseases a. use of chronic inhaled steroids is not an exclusion 4. receipt of any il-6 inhibitor within 3 months prior to enrollment in the trial 5. pregnancy, due to lack of fetal monitoring capabilities 6. patients enrolled in other interventional clinical trials. patients enrolled in non-interventional studies or receiving non-fda-approved drugs for compassionate use are not excluded. 7. patients whose goal of care is comfort measures only 8. inability to provide informed consent, or absence of a legally authorized representative to provide informed consent. 9. severe psychiatric disease that prevents compliance with typical medical care. 10. participation in another interventional clinical trial for covid-19