- previous history of ards in the last month - chronic respiratory diseases requiring long-term oxygen therapy and/or long-term respiratory assistance - history of organ allograft. - active cancer - liver cirrhosis with basal child and pugh of c - pulmonary fibrosis - patient with end-of-life decision - patient not expected to survive for 24 hours - woman known to be pregnant, lactating or with a positive (urine or serum test) or indeterminate (serum test) pregnancy test - patient already enrolled in another interventional pharmacotherapy protocol on covid-19 - patient with known hypersensitivity to natural or recombinant interleukin-2 or to any of the excipients - presence of any of the following abnormal laboratory values at screening: absolute neutrophil count (anc) less than 1.5x109/l, ast or alt greater than 5 x uln, platelets <50,000 per mm3 - use of chronic oral corticosteroids > 10 mg prednisone equivalent a day for a non-covid-19-related condition - current uncontrolled autoimmune disease - patients with uncontrolled suspected or known active systemic bacterial or fungal infections - patient with severe, uncontrolled pre-existing (chronic) organ failure (myocardial, hepatic or renal) - vaccination with live attenuated vaccines in the month preceding the inclusion - patient with burns to ≥ 15% of their total body surface area - patient receiving extra-corporeal membrane oxygenation, high-frequency oscillatory ventilation or any form of extra-corporeal lung support - patient under legal protection (protection of the court, or in curatorship or guardianship).

- previous history of ards in the last month - chronic respiratory diseases requiring long-term oxygen therapy and/or long-term respiratory assistance - history of organ allograft. - active cancer - liver cirrhosis with basal child and pugh of c - pulmonary fibrosis - patient with end-of-life decision - patient not expected to survive for 24 hours - woman known to be pregnant, lactating or with a positive (urine or serum test) or indeterminate (serum test) pregnancy test - patient already enrolled in another interventional pharmacotherapy protocol on covid-19 - patient with known hypersensitivity to natural or recombinant interleukin-2 or to any of the excipients - presence of any of the following abnormal laboratory values at screening: absolute neutrophil count (anc) less than 1.5x109/l, ast or alt greater than 5 x uln, platelets <50,000 per mm3 - use of chronic oral corticosteroids > 10 mg prednisone equivalent a day for a non-covid-19-related condition - current uncontrolled autoimmune disease - patients with uncontrolled suspected or known active systemic bacterial or fungal infections - patient with severe, uncontrolled pre-existing (chronic) organ failure (myocardial, hepatic or renal) - vaccination with live attenuated vaccines in the month preceding the inclusion - patient with burns to ≥ 15% of their total body surface area - patient receiving extra-corporeal membrane oxygenation, high-frequency oscillatory ventilation or any form of extra-corporeal lung support - patient under legal protection (protection of the court, or in curatorship or guardianship).

- previous history of ards in the last month - chronic respiratory diseases requiring long-term oxygen therapy and/or long-term respiratory assistance - allogeneic bone marrow transplantation - active cancer - liver cirrhosis with basal child and pugh of c - pulmonary fibrosis - patient with end-of-life decision - patient not expected to survive for 24 hours - woman known to be pregnant, lactating or with a positive (urine or serum test) or indeterminate (serum test) pregnancy test - patient already enrolled in another interventional pharmacotherapy protocol - on covid-19 - patient with known hypersensitivity to natural or recombinant interleukin-2 or to any of the excipients - patient with burns to ≥15% of their total body surface area - patient receiving extra-corporeal membrane oxygenation, high-frequency oscillatory ventilation or any form of extra-corporeal lung support - patient under legal protection (protection of the court, or in curatorship or guardianship).

- previous history of ards in the last month - chronic respiratory diseases requiring long-term oxygen therapy and/or long-term respiratory assistance - allogeneic bone marrow transplantation - active cancer - liver cirrhosis with basal child and pugh of c - pulmonary fibrosis - patient with end-of-life decision - patient not expected to survive for 24 hours - woman known to be pregnant, lactating or with a positive (urine or serum test) or indeterminate (serum test) pregnancy test - patient already enrolled in another interventional pharmacotherapy protocol - on covid-19 - patient with known hypersensitivity to natural or recombinant interleukin-2 or to any of the excipients - patient with burns to ≥15% of their total body surface area - patient receiving extra-corporeal membrane oxygenation, high-frequency oscillatory ventilation or any form of extra-corporeal lung support - patient under legal protection (protection of the court, or in curatorship or guardianship).