- patients with mild disease not requiring oxygen therapy - patients with normal cxr & ct scan - patients requiring ventilatory support - patients with a history of allergy to plasma, sodium citrate or methylene blue - patients with a history of autoimmune disease or selective iga deficiency.

- patients with mild disease not requiring oxygen therapy - patients with normal cxr & ct scan - patients requiring ventilatory support - patients with a history of allergy to plasma, sodium citrate or methylene blue - patients with a history of autoimmune disease or selective iga deficiency.