- immunosuppression - pregnancy & lactation - chronic underlying medical illness - known allergy to (components of) the bcg vaccine or serious adverse events to prior bcg administration - known active or latent mycobacterium tuberculosis or with another mycobacterial species. - fever (>38 c) within the past 24 hours - current bacterial infection - recent viral infection - refusal of doing tuberculin test in the first group

- immunosuppression - pregnancy & lactation - chronic underlying medical illness - known allergy to (components of) the bcg vaccine or serious adverse events to prior bcg administration - known active or latent mycobacterium tuberculosis or with another mycobacterial species. - fever (>38 c) within the past 24 hours - current bacterial infection - recent viral infection - refusal of doing tuberculin test in the first group